It's more than natural.
Each and one of us are chemically different. It's like for example in traditional medicine, you have people that the medicine effect is the opposite, that is supposed to be. Some have allergic reactions, some physical rejection and others instead of being calm, with a pill that should relax, they get 100% speed up.
The opposite also happens.
I think we should learn to listen to our body and respect what it tells us, what it works and don't, and honour it.