"I never use methylene blue orally." You can potentially ruin your gut microbiome Tone Vays: "Sticking with the mitochondria, right now I'm testing out a few things. So I've been doing methylene blue for about a month." Dr. Jack Kruse: "How do you do it?" Tone Vays: "Uh, I have a liquid that I put in water." Dr. Jack Kruse: "You don't do that." Tone Vays: "You know, this is what I was going to ask. And I don't feel any different. […] And my biggest problem with it is it's such an artificial thing. I just feel uncomfortable drinking something that was created. […] What are your thoughts on methylene blue? Should an average person use it? Who should use it? And how should they use it if they need to use it?" Dr. Jack Kruse: "The number one thing you need to understand is context. Who are the doctors that are experts in using methylene blue? Cardiovascular surgeons and neurosurgeons. What's my day job? I'm a neurosurgeon. […] "So I want you to understand what methylene blue is really used for. It can be an antimicrobial. So if you're taking it this way [points to his mouth], you're killing your gut microbiome. "The only way cardiovascular surgeons use it and neurosurgeons use it is IV. That's the only way it should be used, and then it knows what they're doing. […] If you take it orally, you potentially can ruin your microbiome. It's a great way to screw things up. Then you make the hole deeper, and then you won't know where to go from there. "So, my two cents, I have a Patreon blog that tells you specifically when and when not to use it. I also believe that you need to have a decentralized doctor under your care to tell you whether it's a good thing for your current template. But I never use methylene blue orally." Dr. Jack Kruse with Tone Vays @ 15:47–17:54 (posted 2025-11-15)