Another unfortunate clinical trial failure for a CNS indication (Parkinson). All primary and secondary endpoints were missed: #science #parkinson #neurodegeneration #brain
This is really interesting: https://www.nature.com/articles/s41562-024-02046-9 "Large language models surpass human experts in predicting neuroscience results" A study on how well trained LLMs can predict the "correctness" of a new neuroscience study/claim based on looking into the associations of the mentioned claims/words in the new study compared to a reference set of thousands of previously published neuroscience papers. The idea here is that there are associations hidden in the vast amount of literature out there that humans in general and singular scientists in particular just cannot read, remember, grasp and comprehend anymore due to the exponential growth in studies. Importantly all thus trained LLMs outperform a large panel of human expert in predicting whether or not a new study or a fake study is true. This is really fascinating and could have major implications to identify new disease MoA hypothesis, target validationa nd dicovery, discover hidden connections and low-hanging treatment option fruits that nobody has yet considered or simply just weed out fake or irrelevant new er publications. #ai #science #neuroscience #drugs #future #LLM #nostr
#bitcoin #nostr #memes image
My favorite euphemism from corporate world is "let's take a bio break"
Today, I experienced a first: someone told me they got interested in Bitcoin after reading my book and now plan to buy some. Made my day to know I finally managed to orange pill someone! #bitcoin #books
Another ALS clinical trial failure: Unfortunate but sad reality when it comes to CNS disorders. The problem mostly stems from our fundamental ignorance (in the classical meaning) when it comes to these disorders. We truly mostly still don't understand what is the underlying key mechanism of action that needs correction in order to treat these diseases. #science #als #brain #motorneurons
Are LLMs better doctors? LLM model on its own far outperforms physicians when giving the correct diagnosis. Funny thing is, even when physicians are allowed to use AI as support, their correct diagnosis ratio basically does not increase, indicating a tendency of the physicians to cling to their own diagnosis and ignoring the LLMs advice. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825395 #ai #science #health
playing around with AI-generating video for scenes from my book. I wanted an intense fight in hotel room between a middle-aged US agent and two Chinese bodyguards. I received a beautiful choreographed modern dance triplet of a Chinese Christopher Walken and two supporting dancers. Long way to go. #ai #art #artstr #books #funny image
ok,this is just beautiful #sun #universe #science