Lite Roasters 4 months ago

most of the day i spend with working class salt of the earth people. every once in awhile money comes up in conversation. everyone from general contractors to nurses are living hand to mouth. paycheck to paycheck there is nothing left at the end of the month to even consider sweeping into bitcoin. it is a luxury to have more than you spend. the ability to save even a few dollars is rare these days.

Lite Roasters 4 months ago

people who yell the loudest are often the people you should try the hardest to ignore

Lite Roasters 4 months ago

tradfi says we need more inflows to grow the asset class bitcoiners say we need less outflows to grow the asset class

Lite Roasters 4 months ago

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://www.cell.com/cell/fulltext/S0092-8674(18)30520-8# >The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered by the KD and required for protection against acute electrically induced seizures and spontaneous tonic-clonic seizures in two mouse models. Mice treated with antibiotics or reared germ free are resistant to KD-mediated seizure protection. Enrichment of, and gnotobiotic co-colonization with, KD-associated Akkermansia and Parabacteroides restores seizure protection. Moreover, transplantation of the KD gut microbiota and treatment with Akkermansia and Parabacteroides each confer seizure protection to mice fed a control diet. Alterations in colonic lumenal, serum, and hippocampal metabolomic profiles correlate with seizure protection, including reductions in systemic gamma-glutamylated amino acids and elevated hippocampal GABA/glutamate levels. Bacterial cross-feeding decreases gamma-glutamyltranspeptidase activity, and inhibiting gamma-glutamylation promotes seizure protection in vivo. Overall, this study reveals that the gut microbiota modulates host metabolism and seizure susceptibility in mice.