Potential monopoly startup ideas:
+ longevity and anti-aging (only Don’t Die and Altos Labs are major players)
+ DeFi Infrastructure—Bitcoin native financial layers or DAOs etc. (no high scale DAOs exist)
+ AI Agents for Scientific Discovery (
📄.pdf)
+ Nuclear Energy (heavy government reliance but Aalo Atomics and Valar Atomics are doing it)
+ Space Infrastructure and Off-Earth Markets—asteroid mining, ultra low cost satellites and bio-habitability tech for outer space (some companies are doing interesting stuff like Longshot Space)
+ AI Alignment Philosophy and Infrastructure (many commentators but David Deutsch is personal favourite)
+ Censorship proof Communication and Infrastructure (x exists but is centralised;
@primal is a good decentralised alternative)
+ Education Alternatives built for the 20th century (lot remains to be done here—synthesis school is a great example)
+ New Nations (the network state)