Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53 https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01395-6

Transactions on micronuclear DNA and implications for immune signaling https://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(25)00248-8

A triple-action PROTAC for wild-type p53 cancer therapy https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00540-3

Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts https://www.sciencedirect.com/science/article/pii/S2666379125004306

p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers https://www.science.org/doi/10.1126/scisignal.adv0415

Metastatic Recurrence Among Adolescents and Young Adults With Cancer https://jamanetwork.com/journals/jamaoncology/fullarticle/2841867

KRAS-targeted therapies in cancer: novel approaches and overcoming resistance https://bmjoncology.bmj.com/content/4/1/e000946

Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01396-8

Congratulations to our colleague Marty Taylor at @BrownMedicine @BrownUniversity Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 https://www.science.org/doi/10.1126/science.adv7111 @DrMartyTaylor

Carl H. June 2025 Balzan Prize for Gene and Gene-Modified Cell Therapy

Fondazione Internazionale Premio Balzan

Carl H. June - Fondazione Internazionale Premio Balzan

2025 Balzan Prize for Gene and Gene-Modified Cell Therapy